Author’s response to reviews Title: Whole exome sequencing reveals a stop-gain mutation of PKD2 in an autosomal dominant polycystic kidney disease family complicated with aortic dissection Authors:

Thank the editor and reviewers for these precious comments concerning my manuscript entitled "Whole exome sequencing reveals a stop-gain mutation of PKD2 in an autosomal dominant polycystic kidney disease family complicated with aortic dissection" (MGTC-D-17-00066R1). These comments are all valuable and very helpful for revising and improving my paper, as well as the important guiding significance to my researches. We have studied comments carefully and have made corrections which we hope meet with approval. Their original critiques are highlighted in bold and italic, followed by our response.